Chapter 12: Advanced Prompt Engineering Techniques
Mastering sophisticated approaches to interacting with Large Language Models

This module builds on foundational prompt engineering concepts to explore advanced techniques that significantly enhance the capabilities of Large Language Models (LLMs). You'll learn sophisticated approaches to structuring prompts, optimizing for specific use cases, and leveraging the latest developments in the field as of 2025.
Tree-of-Thought Prompting
Tree-of-Thought (ToT) prompting encourages the LLM to explore multiple reasoning paths before arriving at a solution, mimicking human-like problem-solving. This technique is particularly effective for complex problems that benefit from considering different approaches.
Example Prompt:
"Let's solve this math problem step by step. Consider three different approaches to solving it, then evaluate which approach is most likely to be correct. Finally, provide the answer using the best approach. Problem: If a train travels 300 miles in 5 hours, what is its average speed?"
Visualizing Tree-of-Thought
The diagram shows how the LLM explores multiple reasoning paths (branches) before selecting the most promising one (highlighted in green).
Python Implementation
from transformers import AutoModelForCausalLM, AutoTokenizer
model_name = "mistralai/Mixtral-8x22B-v1"
tokenizer = AutoTokenizer.from_pretrained(model_name)
model = AutoModelForCausalLM.from_pretrained(model_name)
def tree_of_thought_prompt(problem):
prompt = f"""Let's solve this problem by exploring multiple approaches:
Problem: {problem}
Approach 1: [First approach details]
Approach 2: [Second approach details]
Approach 3: [Third approach details]
Evaluation of approaches:
1. [Evaluate approach 1]
2. [Evaluate approach 2]
3. [Evaluate approach 3]
Best approach: [Select and justify]
Solution using best approach: [Provide solution]"""
inputs = tokenizer(prompt, return_tensors="pt")
outputs = model.generate(**inputs, max_length=500)
return tokenizer.decode(outputs[0], skip_special_tokens=True)
print(tree_of_thought_prompt("If a train travels 300 miles in 5 hours, what is its average speed?"))
Key Benefits:
- Increases accuracy on complex problems by 15-30% compared to single-path reasoning
- Makes the model's reasoning process more transparent
- Reduces "reasoning shortcuts" where models jump to conclusions
Self-Reflective Prompting
Self-reflective prompting asks the model to examine and critique its own reasoning process. This meta-cognitive approach helps identify flaws in the model's initial responses and leads to more reliable outputs.
Basic vs. Reflective Prompt
Basic Prompt:
"Explain the causes of World War I."
Reflective Prompt:
"Explain the causes of World War I. After providing your explanation, analyze whether you might have missed any important factors, and if so, revise your answer accordingly."
Example Output
Initial Answer:
"The main causes were militarism, alliances, imperialism, and the assassination of Archduke Franz Ferdinand."
Self-Reflection:
"I may have overlooked the role of nationalism as a contributing factor, and the complex economic rivalries between powers."
Revised Answer:
"In addition to militarism, alliances, imperialism, and the assassination, rising nationalism in the Balkans and economic competition between imperial powers were significant factors..."
When to Use Self-Reflective Prompting
- ✓ When factual accuracy is critical
- ✓ For complex, multi-faceted questions
- ✓ When identifying potential biases
- ✓ For creative tasks requiring iteration
Prompt Optimization for Specific Domains
Different domains require specialized prompt structures to get the best results from LLMs. Below are examples for legal, medical, and creative writing domains.
Legal Prompts
Example:
"Analyze this contract clause for potential liabilities, citing relevant California business law statutes. Provide your analysis in three parts: 1) Key terms, 2) Potential risks, 3) Recommended revisions."
Tip: Include jurisdiction and request structured output.
Medical Prompts
Example:
"For a patient with these symptoms [list symptoms], provide a differential diagnosis ordered by likelihood. For each possibility, list: 1) Supporting symptoms, 2) Ruling-out criteria, 3) Recommended tests."
Tip: Emphasize evidence-based reasoning.
Creative Writing
Example:
"Write a 300-word sci-fi story opening set on Mars. Include: 1) Vivid sensory details, 2) A character with a clear desire, 3) Foreshadowing of the main conflict. Use a tone that's hopeful but with underlying tension."
Tip: Specify emotional tone and structural elements.
Domain-Specific Prompt Template
"""You are an expert in [DOMAIN] with [X] years of experience. Your task is to [TASK DESCRIPTION].
Required elements in your response:
1. [First required element]
2. [Second required element]
3. [Third required element]
Format your response using [SPECIFIED FORMAT].
Important considerations:
- [DOMAIN-SPECIFIC CONSIDERATION 1]
- [DOMAIN-SPECIFIC CONSIDERATION 2]
Begin your response with a [SPECIFIED INTRODUCTION], and conclude with [SPECIFIED CONCLUSION]."""
Automated Prompt Engineering
Recent advances allow using LLMs themselves to optimize prompts automatically. This section covers practical techniques and tools available in 2025.
Prompt Optimization Loop
- Generate multiple prompt variations
- Test each against validation examples
- Score outputs using metrics (accuracy, completeness)
- Select top performers for refinement
- Repeat until convergence
Popular Tools (2025):
- 1 PromptPerfect - Cloud-based prompt optimizer
- 2 OptiPrompt - Open-source Python library
- 3 PromptTuner - Integrates with Hugging Face
Python Example
from prompt_optimizer import EvolutionaryOptimizer
# Define your base prompt
base_prompt = "Explain quantum computing"
# Define evaluation function (simplified)
def evaluate(prompt_variant):
response = llm.generate(prompt_variant)
return score_response(response)
# Set up optimizer
optimizer = EvolutionaryOptimizer(
base_prompt=base_prompt,
evaluation_func=evaluate,
population_size=20,
mutation_rate=0.1
)
# Run optimization
best_prompt = optimizer.optimize(generations=5)
print(f"Optimized prompt: {best_prompt}")
# Sample output might produce:
# "Explain quantum computing to a computer science undergraduate,
# using analogies from classical computing and 2-3 key equations."
Current Limitations:
- Requires significant compute resources for thorough optimization
- Evaluation metrics can be challenging to define for subjective tasks
- May produce prompts that overfit to specific models
Multi-Modal Prompting
With models like GPT-5 and Gemini 2.0 supporting multiple input modalities, prompts can now combine text, images, and other data types for richer interactions.
Use Cases
Medical Diagnosis
Combine patient history (text) with X-ray images for more accurate assessments.
E-Commerce
Upload product images with text descriptions to generate optimized listings.
Education
Submit math problem photos with handwritten work for step-by-step feedback.
API Example
from openai import OpenAI
import base64
client = OpenAI()
def encode_image(image_path):
with open(image_path, "rb") as image_file:
return base64.b64encode(image_file.read()).decode('utf-8')
response = client.chat.completions.create(
model="gpt-5-vision-preview",
messages=[
{
"role": "user",
"content": [
{"type": "text", "text": "Analyze this medical image and describe any abnormalities."},
{
"type": "image_url",
"image_url": {
"url": f"data:image/jpeg;base64,{encode_image('xray.jpg')}"
},
},
],
}
],
max_tokens=500,
)
print(response.choices[0].message.content)
Best Practices for Multi-Modal Prompts
- ✓ Explicitly reference the visual elements in your text prompt
- ✓ Provide context about why you're including the image
- ✓ For complex images, guide the model's attention ("Focus on the upper right quadrant")
- ✓ Combine with other techniques like chain-of-thought when appropriate
Handling Long Contexts
While modern LLMs support longer contexts (up to 1M tokens in some 2025 models), effective prompt engineering for long documents requires special techniques.
Strategies for Long Documents
Hierarchical Processing
First summarize sections, then process summaries:
1. Split document into logical sections 2. Generate summaries of each section 3. Process the concatenated summaries 4. Optionally drill down into specific sections
Recursive Questioning
Maintain context through a question-answer chain:
Q1: What are the main themes in this document? A1: [Themes listed] Q2: Regarding theme 3, what evidence supports it? A2: [Evidence details] Q3: What counterarguments exist for point 2 of evidence?
Python Implementation
from transformers import AutoTokenizer, AutoModelForCausalLM
from langchain_text_splitters import SemanticChunker
model_name = "anthropic/claude-3-200k"
tokenizer = AutoTokenizer.from_pretrained(model_name)
model = AutoModelForCausalLM.from_pretrained(model_name)
def process_long_document(text, question):
# Split document into meaningful chunks
splitter = SemanticChunker()
chunks = splitter.create_documents([text])
# First pass: Summarize each chunk
summaries = []
for chunk in chunks:
prompt = f"Summarize this text in 2-3 sentences:\n\n{chunk}"
inputs = tokenizer(prompt, return_tensors="pt")
summary = model.generate(**inputs, max_length=150)
summaries.append(tokenizer.decode(summary[0], skip_special_tokens=True))
# Second pass: Answer question using summaries
context = "\n\n".join(summaries)
prompt = f"Based on these summaries:\n{context}\n\nQuestion: {question}"
inputs = tokenizer(prompt, return_tensors="pt")
answer = model.generate(**inputs, max_length=500)
return tokenizer.decode(answer[0], skip_special_tokens=True)
# Usage with a long PDF text and specific question
answer = process_long_document(pdf_text, "What are the key risk factors mentioned?")
Performance Considerations
Context Length
128K
Common in mid-range 2025 models
Attention Cost
O(n²)
Grows quadratically with length
Accuracy Drop
15-30%
At 100K vs 10K tokens
Future Trends in Prompt Engineering (2025)
The field of prompt engineering continues to evolve rapidly. Here are the most significant developments as of mid-2025:
Neuro-Symbolic Prompting
Combining neural networks with symbolic AI for more structured reasoning:
"Solve this physics problem by: 1) Extracting given quantities (symbolic) 2) Identifying relevant equations (symbolic) 3) Executing calculations (neural) 4) Verifying dimensional consistency (symbolic)"
Personalized Prompting
Models that adapt to individual user's communication styles and preferences:
- Learns from your past interactions
- Adapts verbosity and formality
- Remembers domain preferences
Multi-Agent Prompting
Orchestrating multiple specialized agents for complex tasks:
"For this market analysis task: 1) Have the Researcher gather data 2) Have the Analyst identify trends 3) Have the Writer draft the report 4) Have the Editor polish the output Coordinate between agents and synthesize final result."
Embedded Prompt Tuning
Continuous prompt optimization during deployment:
- Real-time adaptation to new data
- A/B testing of prompt variations
- Automatic performance monitoring
Ethical Considerations
As prompting techniques become more sophisticated, important ethical questions emerge:
- ! Transparency about when and how prompts are being optimized
- ! Preventing prompt engineering from becoming a "hidden" skill barrier
- ! Ensuring prompts don't inadvertently embed biases
- ! Developing standards for reproducible prompt engineering
Key Takeaways
Reasoning Techniques
Tree-of-Thought and Self-Reflective prompting significantly improve model reasoning capabilities.
Domain Specialization
Tailoring prompts to specific domains yields dramatically better results.
Automation
Prompt engineering itself is becoming automated through AI tools.
Multi-Modality
Combining text with other data types enables richer applications.
Scalability
New techniques help manage long contexts effectively.
Future Directions
Neuro-symbolic approaches and multi-agent systems represent the next frontier.